年长的PLHIV患有更高的心血管风险,生活质量差
Muhammed Shabil1, Krishna Murti1, V Udaya Kumar1
1Department of Pharmacy Practice, National Institute of Pharmaceutical Education and research, Hajipur, 844102, India.
Current HIV research
|December 23, 2023
概括
印度艾滋病毒感染者 (PLHIV) 的老年人面临显著更高的心血管疾病 (CVD) 风险. 年龄和BMI是关键的预测指标,突出显示了对此种人群进行量身定制的心血管疾病风险评估和管理的需要.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 老年学是一门学科.
背景情况:
- 艾滋病毒感染者 (PLHIV) 由于慢性炎症和免疫激活,心血管疾病 (CVD) 风险增加.
- 老龄化加剧心血管疾病风险,但印度老年PLHIV的数据仍然有限,这个国家有214万个PLHIV.
- 在PLHIV中,心血管疾病风险因素的更高患病率需要集中研究,特别是在老龄化人口中.
研究的目的:
- 评估和比较心血管疾病 (CVD) 风险在老年PLHIV与年轻的PLHIV和非艾滋病毒个体在比哈尔,印度.
- 评估弗雷明汉风险评分 (FRS) 和Qrisk3在确定老年PLHIV患者心脏病风险方面的有效性.
- 调查老年PLHIV患者的生活质量 (QoL) 以及其与心血管疾病风险因素的相关性.
主要方法:
- 一项涉及73名PLHIV和30名印度比哈尔州的对照参与者的横截面研究.
- 收集人口,社会,临床数据和心血管疾病风险因素,包括HbA1c和脂质资料.
- 使用弗雷明汉风险评分 (FRS) 和Qrisk3计算10年心血管疾病风险,并使用WHOQOL-HIV-BREF评估QOL.
主要成果:
- 与年轻的PLHIV和非HIV对照相比,老年PLHIV的平均FRS和Q风险得分显著更高.
- 六名老年PLHIV参与者被FRS归类为高心血管疾病风险,而其他组的参与者没有达到这一门.
- 在老年PLHIV患者中, QoL 的心理,社会关系和精神领域的恶化被注意到.
结论:
- 印度的老年PLHIV面临不成比例地更高的心血管疾病风险,强调需要有针对性的风险评估和管理策略.
- FRS和Q-风险得分是有效的工具,用于识别较老的PLHIV患者心血管疾病风险升高,年龄和BMI是重要的预测因素.
- 这项研究强调了老年PLHIV患者中适度的QOL恶化,特别是在心理,社会和精神方面,需要综合护理方法.
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