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作为AMPK激活剂的2'-基甲衍生物的合成和生物评估

Duy Vu Nguyen1, Chatchai Muanprasat2, Suchada Kaewin3

  • 1Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand.

Bioorganic chemistry
|December 23, 2023
PubMed
概括

合成了新的石墨烯衍生物,并对AMP激活蛋白激酶 (AMPK) 激活进行了测试. 化合物27和29在细胞中显示出显著的AMPK激活,而化合物27被确定为有前途的治疗候选物.

关键词:
这是一种2′-基基子.激活AMPK的激活方式这就是为什么CaMKKββ.分子对接研究分子对接研究波多细胞 (Podocytes) 是一种细胞.结构与活动的关系.

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