产周发皮质醇度与心理困扰和意外的分娩并发症有关
J A Madigan1, Sara F Waters2, Maria A Gartstein3
1School of Biological Sciences, Washington State University, Pullman, WA 99164, USA; Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA.
Psychoneuroendocrinology
|December 23, 2023
概括
怀孕期间母亲的头发皮质醇度 (HCC) 与心理困扰有关,并预测不可预测的分娩并发症 (UBC). 高水平的HCC在分娩后持续存在,强调需要监测母亲的压力和皮质醇水平.
科学领域:
- 生殖医学和围产期健康
- 内分泌学和压力生理学生理学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 假设产前期母亲的心理健康和压力会影响出生结果和后代的发展.
- 头发皮质醇度 (HCC) 提供了慢性皮质醇暴露的回顾性测量,反映了长期的压力.
- 了解母亲的压力,皮质醇水平和分娩并发症之间的关系对于产周护理至关重要.
研究的目的:
- 为了调查头发皮质醇度 (HCC) 与围产期心理困扰症状之间的联系.
- 探索HCC和意外出生并发症 (UBCs) 之间的关系.
- 检查HCC和心理困扰在围产期的变化与出生结果的关系.
主要方法:
- 收集了53名孕妇在孕期第三季度以及分娩后2个月和6个月期间感知到的压力,焦虑和抑郁的调查数据.
- 测量了从参与者的小组中在妊娠第三季度和出生后六个月收集的头发样本中的头发皮质醇度 (HCC).
- 利用后勤回归和重复测量MANOVA来分析HCC,心理困境得分 (SAD) 和UBC之间的关系.
主要成果:
- 报告UBC的参与者在产后两个月显著增加了压力,焦虑和抑郁症 (SAD) 评分,该评分下降了六个月.
- 第三季度的HCC与SAD得分有积极关联,并且在经历过分娩并发症的参与者中升高.
- 头发皮质醇度 (HCC),而不是SAD得分,显著预测的UBCs (p=0.023). 在产前期,HCC水平因SAD分数和UBCs的影响而有所不同.
结论:
- 研究结果支持怀孕期间和产后早期心理痛苦与HCC之间的积极关联.
- 怀孕期间慢性升高的HCC与UBC风险增加有关,并持续到产后早期.
- 在产周期期间,监测心理困扰和HCC是很重要的,因为它们与分娩并发症有关.
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