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针膀午线通过HMGB1缓解焦虑症

Ping Lu¹, Qi Zhang², Zhiyang Yin²

¹Department of Tuina, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China; School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China; Institute of Tuina, Shanghai Institute of Traditional Chinese Medicine, Shanghai, PR China.

International immunopharmacology

|December 23, 2023

概括

针膀午线 (ABM) 通过减少氧化应激和炎症来缓解老鼠的焦虑. 这种疗法针对依赖于活性氧物种 (ROS) 的高流动性组第1框 (HMGB1) 信号通路.

科学领域:

神经科学是一个神经科学.
整合和补充医学是整合和补充医学.
压力研究压力研究

背景情况:

慢性压力是导致焦虑症的一个重要因素.
氧化应激和炎症与焦虑的病理生理学有关.
膀午线是中国传统医学的关键途径.

研究的目的:

为了研究针治疗膀午线 (ABM) 对慢性压力的老鼠模型中的焦虑的影响.
阐明ABM抗焦虑效应的潜在机制,重点关注氧化应激和炎症.

主要方法:

遭受慢性压力的老鼠被用ABM治疗.
行为测试 (偏好糖水,尾部悬浮,强迫游泳) 用于评估类似焦虑的行为.
在海马组织中测量了活性氧物种 (ROS),髓氧化酶 (MPO),氧化应激标志物和炎症性细胞因子的水平.
使用脂聚糖 (LPS) 刺激的PC12细胞和HMGB1敲击进行了体外研究,以探索分子机制.

主要成果:

在老鼠中,ABM显著减少了类似焦虑的行为.
ABM治疗降低了ROS,MPO,氧化应激标志物和炎症性细胞因子的水平.
ABM调节了高流动性组盒子1 (HMGB1) 信号通路,减少了炎症并增加了Nrf-2/HO-1抗氧化剂通路.
在体外实验证实了ABM的抗炎作用及其激活Nrf-2/HO-1通路的能力.

结论:

依赖活性氧物种 (ROS) 的HMGB1在焦虑的发展中起着至关重要的作用.
针治疗膀 меридиан (ABM) 显示出抗炎作用,并减轻焦虑,可能通过HMGB1和Nrf-2/HO-1通道.

关键词:

针按压膀午线针按压膀午线焦虑焦虑是一种焦虑.这就是HMGB1的特点.炎症炎症是一种炎症.这就是ROSOS ROS.

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