在激素受体阳性/HER2阴性乳腺癌中进行新辅助疗法
Luca Cantini1, Dario Trapani2, Lorenzo Guidi2
1Fortrea Inc., Durham, NC, USA.
Cancer treatment reviews
|December 23, 2023
概括
新辅助化疗 (NACT) 和新辅助内分泌疗法 (NET) 是HR+/HER2-乳腺癌 (BC) 的选择. 生物标志物驱动的选择对于优化新辅助治疗和改善治疗结果至关重要.
科学领域:
- 在瘤学瘤学.
- 乳腺癌研究研究 乳腺癌研究
- 新辅助疗法是一种新辅助疗法.
背景情况:
- 新辅助化疗 (NACT) 已为HER2阳性和三阴性乳腺癌 (BC) 确立,有助于瘤衰退和完全反应.
- 对于激素受体阳性,HER2阴性 (HR+/HER2-) BC,治疗选择 (NACT与新辅助内分泌疗法/NET) 缺乏生物标志物指导,与辅助设置不同.
研究的目的:
- 对HR+/HER2-BC中NACT和NET进行比较的证据进行审查.
- 讨论临床试验设计和患者选择新辅助疗法.
- 为HR+/HER2-BC.提出未来生物标志物驱动的新辅助剂战略的路线图.
主要方法:
- 在HR+/HER2-乳腺癌中新辅助疗法的文献综述.
- 分析当前的临床试验设计和患者选择标准.
- 检查新兴疗法,如抗体与药物联合体 (ADC) 和免疫疗法.
主要成果:
- 目前HR+/HER2-BC的治疗决策依赖于临床/病理特征,而不是预测生物标志物.
- 需要超越二元响应者/非响应者评估,转向连续的终点.
- 在多个时间点利用生物标志物可以根据治疗敏感性个性化新辅助疗法.
结论:
- 未来针对HR+/HER2-BC的新辅助剂应采用分阶段,生物标志物驱动的选择过程.
- 个性化治疗选择旨在改善手术结果和长期患者终点.
- 结合组织和血生物标志物是释放新辅助疗法的全部潜力的关键.
相关概念视频
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
208
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
208
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
167
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
167
Tumor Immunotherapy
529
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
529


