功能性MRI肺部的评估胎儿,提供非常早产:一个MRI试点研究研究
Carla L Avena-Zampieri1, Jana Hutter2, Alena Uus3
1Department of Women and Children's Health King's College London, United Kingdom; Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, United Kingdom.
European journal of obstetrics, gynecology, and reproductive biology
|December 23, 2023
概括
预定为非常早产的胎儿的平均肺T2*值和肺体积较低. 这些胎儿肺部MRI发现可能会预测怀孕32周之前的早产.
科学领域:
- 胎儿医学 胎儿医学
- 放射学 放射学是一门学科.
- 新生儿科学 新生儿科学
背景情况:
- 32周前的早产与显著的肺部发病率有关.
- 胎儿肺部发育和氧化水平的产前评估对于预测结果至关重要.
研究的目的:
- 为了比较早产 (<32周) 和对照胎儿的平均肺T2*值和肺体积.
- 评估平均肺T2*作为32周怀孕前自发早产的预测指标.
主要方法:
- 胎儿MRI在3T进行在早产和对照胎儿.
- 使用T2*序列生成T2*地图并计算平均肺T2*值.
- 肺体积被手动细分;线性回归和ROC曲线分析了预测值.
主要成果:
- 分析了28名早产儿和74名对照胎儿.
- 在早产组中观察到较低的平均肺T2*值和体积 (p < 0.001).
- 肺体积和平均T2*值预测了早产 (<32周),AUC分别为0.828和0.754.
结论:
- 较低的产前平均肺T2*值和肺体积表明胎儿肺氧化和发育发生了变化.
- 这些发现表明,在非常早产的婴儿中,肺部发病的潜在产前病例.
- 需要进一步研究,将产前MRI发现与长期肺部结果相关联.
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