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骨髓细胞ACE2通过Ang-(1-7) -Mas介导的巨细胞两极分化,防止败血性低血压和血管功能障碍

Jia-Xin Li¹, Xue Xiao¹, Fei Teng¹

¹Department of Emergency Medicine, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Worker's Stadium South Road, Beijing, 100020, China.

|December 23, 2023

概括

ангиотензин转化酶2 (ACE2) 通过保持氨酸- ангиотензин- 阿尔多斯特系统的平衡,防止败血症引起的低血压. 升级ACE2可能为败血症休克提供一种新疗法.

科学领域:

生物化学生物化学
免疫学免疫学免疫学
心血管生理学心血管生理学

背景情况:

氨酸- ангиотензин- алдостерон系统 (RAAS) 调节血压.
ангиотензин转化酶2 (ACE2) 将 ангиотензин II (Ang II) 代谢成Ang (1-7),它具有保护作用.
ACE2在败血症引起的低血压中的作用尚不清楚.

研究的目的:

调查ACE2在与败血症相关的低血压中的功能作用.
确定ACE2在败血症中的保护机制.

主要方法:

在ACE2敲进和敲除小鼠中诱导败血症.
骨髓移植的实验. 骨髓移植的实验.
在体外细胞培养研究.
分析血压,死亡率,血管功能,氧化应激,氧化 (NO) 生产和巨细胞两极分化.

主要成果:

败血症降低了血压,并破坏了ACE-Ang II/ACE2-Ang (1-7) 的平衡.
在ACE2敲入小鼠中,在败血症期间显示出改善的生存率和降低的低血压和血管功能障碍.
绝杀ACE2的小鼠表现出恶化的败血症表型.
骨髓细胞ACE2通过通过Ang (1-7) -MasR-NF-κB和STAT1通路抑制氧化应激,NO生产和巨细胞两极分化来防止败血症.

结论:

骨髓细胞ACE2在减轻败血症引起的低血压和血管功能障碍方面发挥着关键的保护作用.
升调ACE2为患有低血压的败血症患者提供了潜在的治疗策略.

关键词:

在ACE2中,ACE2是ACE2.血压下降血压下降血压下降巨细胞的两极分化败血症这是一种败血症.血管功能障碍血管功能障碍

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