在COVID-19患者中与更年期状态相关的发生率和结果:系统性审查和元分析
Abolfazl Akbari1, Ahmadreza Zarifian1,2, Alireza Hadizadeh3
1Mashhad University of Medical Sciences, Mashhad, Iran.
概括
与年龄相匹配的男性相比,更年期前妇女的COVID-19发病率高于更年期后妇女. 虽然结果可能对绝经前妇女更好,但雌激素,雌激素.
科学领域:
- 生殖内分泌学和传染病研究.
- 研究激素变化对病毒感染易感性和严重性的影响.
背景情况:
- 更年期显著改变女性生理学,可能会影响免疫反应.
- 了解更年期状态如何影响COVID-19 (冠状病毒疾病2019) 易感性和结果至关重要.
研究的目的:
- 检查更年期状态与COVID-19的发病率和结果之间的关联.
- 为了比较更年期前和更年期后妇女的COVID-19感染率和严重程度.
主要方法:
- 关于COVID-19在绝经前和绝经后妇女中的研究的系统审查和元分析.
- 搜索了PubMed,Embase,Web-of-Science和Scopus的相关文献,截至2022年12月29日.
- 分析比较了绝经前妇女和同龄男性的COVID-19发病率.
主要成果:
- 分析显示,与同龄男性相比,绝经前妇女的COVID-19发病率更高 (OR=1.270,p=0.003).
- 大多数研究表明,绝经前妇女的COVID-19结果更好,尽管有些人发现绝经后妇女的结果更好或没有关联.
- 对结果的相互矛盾的结果凸显了更年期状态的角色的复杂性.
结论:
- 与绝经后妇女相比,绝经前妇女的COVID-19发病率明显高于绝经后妇女相对于年龄相匹配的男性.
- 雌激素在绝经前妇女中对COVID-19发病率和结果的潜在保护作用仍然没有得到证实.
- 需要进一步的纵向研究来澄清更年期状态和COVID-19之间的关系.
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