多重血液金属与全身动脉样硬化的关联:在CAD患者群体中的横截面研究
Yapei Sun1, Qi Mao2, Denglu Zhou2
1Center of Laboratory Medicine, Chongqing Prevention and Treatment Center for Occupational Diseases, Chongqing 400060, China; Chongqing Key Laboratory of Prevention and Treatment for Occupational Diseases and Poisoning, Chongqing 400060, China; School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Chemosphere
|December 23, 2023
概括
暴露于混合金属显著增加了冠状动脉疾病 (CAD) 患者的系统性动脉样硬化,特别是在外周和动脉. 减少环境金属暴露可能有助于减轻这种风险.
科学领域:
- 环境健康 环境健康
- 心血管疾病研究研究
- 毒理学 毒理学 毒理学
背景情况:
- 冠状动脉疾病 (CAD) 经常与外周动脉样硬化同时发生,增加缺血和心血管死亡的风险.
- 虽然特定的金属暴露与动脉样硬化斑有关,但混合金属对CAD患者系统性动脉样硬化的影响仍未得到充分研究.
研究的目的:
- 为了检查金属混合物和系统性动脉样硬化在CAD患者群体中的负担之间的关联.
主要方法:
- 一项横截面研究涉及来自中国西南部的1562名CAD患者.
- 使用感应合血谱测量量血金属水平 (10种金属).
- 系统性动脉样硬化是通过冠状动脉,动脉和下肢动脉的病变存在/数量来评估的,使用贝叶斯核机回归和加权定量回归来分析.
主要成果:
- 在混合金属暴露和系统性动脉样硬化负担之间观察到显著的积极关联.
- (Cd),铜 (Cu) 和 (Pb) 是系统性动脉样硬化的主要驱动因素.
- (As) 和Cu有助于冠状动脉样硬化,而Cd,Cu和Pb则影响了大脑动脉和下肢动脉样硬化. 观察到Cd与Pb之间的相互作用,以及Pb与年龄,性别和酒精的相互作用.
结论:
- 联合金属暴露与CAD患者系统性动脉样硬化负担的增加密切相关.
- 这些关联在外周和动脉中更为明显.
- 缓解环境金属暴露可能是减少系统性动脉样硬化在这个患者群体的一个策略.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
94
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
94
01:27Psychoneuroimmunology: Cardiovascular Disease
31
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
31