用于药物输送应用的基于凝的水凝的合成和表征
Hussam Y Alharbi1, Rua B Alnoman1, Majed S Aljohani1
1Chemistry Department, Faculty of Science, Taibah University, Yanbu, Saudi Arabia.
International journal of biological macromolecules
|December 23, 2023
概括
研究人员开发了使用Diels-Alder化学物质用于药物输送的新型凝水凝. 这些生物相容的水凝显示出有望针对性地传递特拉马多尔,在胃中有效封装并在肠道中释放.
科学领域:
- 聚合物化学 聚合物化学
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 凝 (Gel) 是一种多用途的多糖体,具有生物医学应用的潜力.
- 开发高效和生物相容的药物输送系统仍然是制药行业的一个关键挑战.
- 水性迪尔斯-阿尔德化学为凝形成提供了一种绿色和无启动剂的方法.
研究的目的:
- 通过使用Diels-Alder化学合成和表征新的基于凝的水凝 (Gel-FM).
- 评估这些水凝作为药物载体的潜力,使用特拉马多尔作为模型药物.
- 在模拟生理条件下研究体外药物释放特征.
主要方法:
- 马利米德和富兰功能化的凝的合成.
- 通过水性Diels-Alder点击化学形成水凝.
- 水凝性质的表征:凝,形态,胀,生物降解,机械性质和抗菌活性.
- 在酸性和性条件下在37°C的酸缓冲盐溶液 (PBS) 中进行特拉马多尔体外封装和释放研究.
主要成果:
- 成功合成了无启动剂,交联的具有定义化学结构的凝水凝 (Gel-FM).
- 凝-FM水凝表现出良好的特性,包括良好的胀,生物降解,以及具有低储存模量的机械特性.
- 水凝证明了安全性和抗菌活性.
- 特拉马多尔在酸性条件下 (胃模拟) 有效封装,在略有性条件下 (肠道模拟) 更快地释放.
结论:
- 开发的基于凝的水凝是安全的,生物相容的,并且具有适合药物输送应用的特性.
- 响应pH的药物释放概况表明有针对性输送的潜力,特别是在结肠.
- 这些水凝代表了先进制药配方和向药物输送系统的有希望的新平台.
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