开发基于麻粉的薄膜,并加入由亚马逊真菌产生的化合物
Lucas de Souza Falcão1, Isabella de Lima Oliveira2, Raiana Silveira Gurgel3
1School of Technology, Amazonas State University, UEA, Manaus, AM, Brazil; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, UNIFESP, Diadema, SP, Brazil.
International journal of biological macromolecules
|December 23, 2023
概括
麻粉膜中含有来自内性真菌Aspergillus niger MgF2的抗氧化化合物,显示出药物输送的潜力. 这些生物相容薄膜确保活性化合物的持续释放,保持药物和化品应用的有效性.
科学领域:
- 生物材料科学 生物材料科学
- 药理学 药理学 是一个学科.
- 菌类学 菌类学是指菌类学.
背景情况:
- 药物释放系统比传统的输送方法具有优势,包括局部管理和长时间的治疗水平.
- 基于粉的薄膜是适合控制药物释放的生物相容和无毒矩阵.
- 内生真菌,如Aspergillus niger,是具有抗氧化特性的生物活性分子的来源.
研究的目的:
- 开发和描述麻粉基薄膜,用于控制抗氧化剂化合物的释放,来自内生真菌Aspergillus nigerMgF2.2.
- 评估开发的药物释放系统的释放动力学,抗氧化活性和细胞毒性.
主要方法:
- 麻粉薄膜被制备,其中包含了来自Aspergillus nigerMgF2.2.的提取物.
- 电影的物理化学性质的特征.
- 实验室释放研究在37°C和pH值6.8.8下进行.
- 对释放的化合物进行了抗氧化和细胞毒性测试.
主要成果:
- 基于粉的薄膜显示了真菌提取物的受控释放,25分钟后观察到的最大释放.
- 释放的抗氧化物化合物保留了它们的生物活性.
- 该配方表现出无毒的特性,表明良好的生物相容性.
结论:
- 含有Aspergillus niger MgF2提取物的木粉膜显示出作为药物释放系统的巨大潜力.
- 这些膜保持了释放的化合物的抗氧化活性.
- 这些发现凸显了生物技术在制药和化品行业的应用潜力.
相关概念视频
01:27Microbes in the Production of Fermented Foods
Lactic acid bacteria (LAB) and molds are instrumental in fermenting plant-based foods to enhance preservation and ensure year-round availability. These microbial processes convert plant carbohydrates into organic acids and other metabolites that inhibit spoilage organisms and contribute to the sensory qualities of the final product.In sauerkraut production, cabbage goes through a microbial succession that starts with cocci such as Leuconostoc mesenteroides. These microbes begin fermentation by...
01:25Production of Organic Acids
Lactic acid, an important organic acid extensively applied in food, pharmaceutical, and biodegradable polymer industries, is primarily produced via microbial fermentation. This method is favored over chemical synthesis due to its environmental sustainability and capacity for enantiomerically pure product formation. Among various microbial processes, the fermentation of starch-based substrates stands out due to the abundance and renewability of raw materials like corn and potatoes.Hydrolysis of...
01:27Bioplastics
Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...