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ADP-ribosylation:一种新兴的疾病治疗方向

Yu-Ting Liu¹, Yan Che¹, Hong-Liang Qiu¹

¹Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan 430060, PR China.

Ageing research reviews

|December 23, 2023

概括

通过ADP-ribosyltransferases (ARTs) 调节的关键翻译后修饰ADP-ribosylation (ADPr) 在细胞过程和疾病中起着至关重要的作用. 对ART介导ADPR的研究为各种疾病提供了新的诊断和治疗策略.

科学领域:

生物化学和分子生物学
细胞信号传输细胞信号传输
疾病机制疾病机制

背景情况:

ADP-ribosylation (ADPr) 是一种可逆的翻译后修饰 (PTM),对细胞功能至关重要.
ADP-ribosyltransferases (ADPRTs或ARTs) 催化ADP-ribose单位的转移,调节各种生物途径.
ADPR的失调与各种病理有关,包括癌症,心血管,神经肌肉和传染病.

研究的目的:

审查了解ART介导的ADP-ribosylation的最新进展.
突出与ADPR相关的疾病的诊断和治疗的最新发现.
在各种病理条件下探索调节ADPR的治疗潜力.

主要方法:

关于ADP-ribosylation和ADP-ribosyltransferases的最新研究的文献综述.
对研究ADPR在疾病发病过程中的作用的分析.
综合与诊断和治疗应用相关的发现.

主要成果:

通过ART介导的ADP-ribosylation是信号传递,DNA修复,新陈代谢,免疫和炎症的组成部分.
新出现的证据将异常ADPR与瘤,心血管,神经肌肉和传染病的发展和进展联系起来.
调节ADPR为新型治疗干预提供了有希望的途径.

结论:

通过ART介导的ADP-ribosylation是一种关键的调节机制,对人类健康有重大影响.
准ART及其基质为开发一系列疾病的创新诊断工具和治疗提供了潜力.
对ADP-ribosylation通路的持续研究对于推进医疗治疗至关重要.

关键词:

在ADP-ribosylation过程中.心血管疾病的心血管疾病.疾病治疗疾病治疗这是一种PARP抑制剂.瘤是一个瘤.

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