对参与结肠直肠癌查进行知情决策的利益危害分析:一项建模研究
Henock G Yebyo1, Francine van Wifferen2, Linda P M Pluymen3
1University of Zurich, Epidemiology, Biostatistics and Prevention Institute, Zürich, Zürich, Switzerland; Ldwig Maximilian University (LMU), Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Public Health and Health Services Research, Munich, Germany.
概括
结肠直肠癌 (CRC) 查为大多数人,特别是男性和那些对查新手提供了净健康益处. 益处随着年龄的增长和查时间的缩短而下降.
科学领域:
- 在瘤学瘤学.
- 预防医学 预防医学
- 健康决策科学健康科学
背景情况:
- 结肠直肠癌 (CRC) 查对于早期检测和改善结果至关重要.
- 关于CRC查参与的知情决策需要清楚地了解其利益与危害的平衡.
- 个体特征和偏好显著影响查的感知价值.
研究的目的:
- 为了评估结直肠癌查在不同亚组的益处危害平衡.
- 评估CRC查在不同时间范围内 (10,20和30年) 的净健康益处.
- 为被邀请参加CRC查的个人提供支持知情决策的数据.
主要方法:
- 利用腺瘤和赛拉特通道到癌症 (ASC) 微模拟模型来估计CRC查的益处和危害.
- 加入了一个偏好引发调查以捕捉个人偏好.
- 根据年龄,性别,查历史和生活方式计算了210个子组的净健康益处.
主要成果:
- 结肠直肠癌查显示,在30年内210个子组中,183个子组显示出健康净益 (中位数概率[MP]0.79).
- 对于男性 (MP 0.82),净健康益处高于女性 (MP 0.76),对于没有先前查史的人 (MP 0.84),与先前查的人 (MP 0.69) 相比,净健康益处更高.
- 福利随着年龄的增长而下降 (55岁的MP为0.84,75岁的MP为0.61) 和时间的缩短 (20年内的MP为0.70,10年内的MP为0.54).
结论:
- 结直肠癌查的益处危害分析为明智决策提供了宝贵的信息.
- 查参与通常是有益的,在人口统计和行为子组中观察到的变化.
- 关于净健康益处的个性化信息可以使查邀请者能够做出个性化的选择.
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