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长期的神经精神病学后果的三角洲与OmicronSARS-CoV-2感染

Liang En Wee¹, Jue Tao Lim², An Ting Tay³

¹National Centre for Infectious Diseases, Singapore General Hospital, Singapore; Duke-NUS Graduate Medical School, National University of Singapore, Singapore; Department of Infectious Diseases, Singapore General Hospital, Singapore.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

|December 23, 2023

概括

长期的COVID可能会增加认知和记忆障碍的风险,特别是在感染Delta变种后. 奥米克朗变种感染与非自愿运动有关,住院患者的风险更高.

科学领域:

神经科学是一个神经科学.
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

之前的研究表明SARS-CoV-2后的长期神经精神病学后果,主要是使用在Omicron和强剂疫苗接种之前的数据.
不同的SARS-CoV-2变种对疫苗接种人群中长期神经健康的影响需要进一步调查.

研究的目的:

估计经过Delta和Omicron BA.1/2感染后新的神经精神病诊断的长期风险和过度负担.
在新加坡的高度接种疫苗和增强成年人队列中比较这些风险.

主要方法:

利用国家SARS-CoV-2测试注册表形成Delta,Omicron BA.1/2和测试负的对照队列.
通过使用国家医疗保健索赔数据,在感染后300天内确定了新发的神经精神病诊断.
雇佣了两倍强大的竞争风险生存分析,以估计风险和过度负担.

主要成果:

认知或记忆障碍显示,Omicron (aHR,1.24) 和Delta (aHR,1.63) 感染后风险增加.
三角洲病毒感染增加了厌氧症/厌经症 (aHR,4.53) 和精神病 (aHR,1.65) 的风险.
奥米克朗感染与非正常的非自愿运动有关 (aHR, 1.93);住院患者的风险最高.

结论:

在SARS-CoV-2感染后的300天内,人们观察到认知和记忆障碍的适度增加,变种特定的差异.
在所有研究领域中,没有发现其他神经精神疾病的风险增加.
在感染德尔塔变种后,无声症/失声症的风险显著增加.

关键词:

无症 (Anosmia) 是一种无症.在 COVID-19 疫情中,认知认知是一种认知.德尔塔德尔塔德尔塔是什么意思神经学神经学这就是Omicron.精神病学是一个精神病学.这就是SARS-CoV-2病毒.

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