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中国对抗生素使用的不同限制水平调整的变化

Kexin Du¹, Haishaerjiang Wushouer², Tao Huang¹

¹Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing, China.

International journal of antimicrobial agents

|December 23, 2023

概括

在中国,调整抗生素限制清单显著减少了抗生素的使用,特别是对于高度受限制的药物. 这些政策变化对于有效的抗微生物药物管理计划至关重要.

科学领域:

药理学药理学是指药理学的学科.
公共卫生政策公共卫生政策
传染病管理传染病管理

背景情况:

抗生素耐药性是全球卫生危机,需要制定优化抗生素使用的战略.
中国的省级抗生素限制清单是抗菌药物管理的关键政策工具.

研究的目的:

调查调整后的省级抗生素限制清单对中国抗生素使用的影响.
分析政策调整后抗生素使用趋势和水平的变化.

主要方法:

从2013年到2019年进行了准实验性中断时间序列分析.
分段回归分析了抗生素使用的趋势和水平变化 (每天1000名患者每天定义的每日剂量).
将调整后限制水平的省份 (干预) 与没有 (比较) 的省份进行比较.

主要成果:

将抗生素从"受限制"类别转移到"高度受限制"类别显著减少了利用率 (P < 0.001),与对照组相比相对下降了100.8%.
在抗生素中观察到明显的趋势变化,这些抗生素在"高度限制"和"限制"类别之间移动.
消费较高的抗生素对限制水平调整的反应更强.

结论:

调整抗生素限制水平是减少抗生素利用的有效策略.
省级抗生素限制清单政策在抗菌药物管理中发挥着至关重要的作用.
有针对性的调整,特别是针对更高的限制水平,可以显著减少抗生素的使用.

关键词:

抗生素的临床使用.抗生素限制清单抗生素限制清单抗微生物药物管理管理中国中国中国中国.时间序列分析中断的分析.

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