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Updated: Jul 7, 2025

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发现和描述新型TRPML1激动剂的发现和特征

Xiaowen Peng1, Christopher J Holler1, Anna-Maria F Alves1

  • 1Arkuda Therapeutics, 200 Arsenal Yards Blvd Suite 220, Watertown, MA 02472, USA.

Bioorganic & medicinal chemistry letters
|December 23, 2023
PubMed
概括

研究人员从10万多种化合物中发现了一种选择性TRPML1激动剂,即化合物1. 这种化合物及其反体是研究TRPML1通道激活在体外和体内有价值的工具.

关键词:
激进主义者的激进主义者阿尔茨海默氏症 (AD) 是一种疾病.溶酶体储存障碍 溶酶体储存障碍第四种类型的粘脂症神经退行发生神经退行.在TRPML1激活过程中.

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