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饮食干预对喘2型炎症标志物的影响:系统性审查
Edith Visser1, Anneke Ten Brinke2, Dionne Sizoo3
1Department of Epidemiology, Medical Centre Leeuwarden, Leeuwarden, the Netherlands; Department of Sustainable Health, Faculty Campus Fryslân, University of Groningen, Leeuwarden, the Netherlands.
Respiratory medicine
|December 23, 2023
概括
目前的证据不支持针对喘2型 (T2) 炎症的特定饮食干预措施. 植物疗法和omega-3脂肪酸显示出希望,但需要在精心设计的研究中进行进一步的研究.
科学领域:
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 2型 (T2) 炎症是喘病理生理学的核心.
- 饮食因素可能会调节免疫反应,影响T2炎症.
- 虽然已知饮食在儿童喘中的作用,但其对成年人喘的影响,通常非喘,理解程度较低.
研究的目的:
- 系统地审查饮食干预措施对成人喘患者T2炎症标志物的影响.
- 为了确定可能影响喘T2炎症的饮食模式或成分.
主要方法:
- 搜索了PubMed,Embase,Cochrane图书馆和CINAHL,直到2022年12月,对患有喘的成人和青少年的饮食干预研究进行了搜索.
- 包括各种饮食因素 (食物,营养素,补充剂) 和与T2生物标志物 (FeNO,乙素,IL-4,IL-5,IL-13,等等) 相关的评估结果. ) 的情况.
- 根据饮食集群评估研究质量和总结研究结果.
主要成果:
- 研究涵盖了饮食集群,包括抗氧化剂,脂肪酸,地中海饮食,植物疗法,益生菌/益生菌和维生素D.
- 植物疗法和omega-3多不和脂肪酸 (PUFA) 显示了T2炎症标志物的潜在改善.
- 有限的证据支持抗氧化剂,益生菌/益生菌和地中海饮食的影响;注意到异质性和研究局限性.
结论:
- 现有证据不证实一种特定的饮食干预措施可以改善喘中的T2炎症.
- 植物疗法和omega-3 PUFA干预措施显示出最有前途的结果,并需要在精心设计的研究中进行进一步的研究.
- 未来的研究应该考虑T2高的喘表型,并采用强大的研究设计.
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