瘤学疲劳的生物标志物:一个系统的审查
Deveny Vanrusselt1, Charlotte Sleurs2, Mahnoor Arif3
1Pediatric Hematology and Oncology, University Hospitals Leuven, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium.
Critical reviews in oncology/hematology
|December 23, 2023
概括
本综述确定了与癌症相关疲劳 (CRF) 相关的非炎症性血液生物标志物,如血红蛋白和BDNF. 这些发现部分支持了炎症性假设,表明神经炎症有助于CRF.
科学领域:
- 在瘤学瘤学.
- 生物标志物研究 生物标志物研究
- 癌症的生存率 癌症的生存率
背景情况:
- 与癌症相关的疲劳 (CRF) 严重损害了癌症患者和癌症幸存者的生活质量.
- 确切的CRF病因尚不清楚,提出的机制包括免疫和HPA轴功能障碍,以及治疗毒性.
- 虽然已经研究了CRF的炎症性生物标志物,但非炎症性标志物仍未得到充分探索.
研究的目的:
- 系统地审查和识别与癌症相关疲劳 (CRF) 相关的非炎症外周血液生物标志物.
- 在CRF的背景下,评估支持炎症性假设的证据.
主要方法:
- 对33项研究进行了系统审查.
- 包括分析与CRF相关的非炎症外周血液生物标志物的研究.
- 数据合成的重点是确定一致和有前途的生物标志物关联.
主要成果:
- 血红蛋白 (Hb),血液凝结因子,来自大脑的神经营养因子 (BDNF),酸盐和增长停止特异性5 (GAA) 被确定为CRF的有前途的非炎症生物标志物.
- 线粒体DNA (mtDNA),金,CA125和cystatin-C也显示出潜在的作用.
- 对于其他标记物,如VEGF,瘦素和压力激素的发现是不一致的.
- 大多数包括的研究集中在成年人群中,在儿科研究有限.
结论:
- 部分证据支持炎症性假设,表明神经炎症诱导的神经毒性可能是CRF的基础.
- 需要进一步的研究,特别是在儿科患者群体中,以验证这些发现,并提前发现CRF的生物标志物.
- 识别可靠的非炎症生物标志物可以改善CRF的管理和理解.
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