焦点细分质硬化症的移植后复发:共识声明
Rupesh Raina1, Swathi Jothi2, Dieter Haffner3
1Department of Nephrology, Akron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, Ohio, USA; Department of Nephrology, Akron Children's Hospital, Akron, Ohio, USA.
Kidney international
|December 23, 2023
概括
移植后的焦点分片质硬化症 (FSGS) 复发导致移植损失. 本综述提出了管理经常性FSGS的共识指南,解决风险因素和治疗,尽管需要更多的研究.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植免疫学 移植免疫学
背景情况:
- 焦点分片球性硬化症 (FSGS) 是性综合征和末期病的主要原因.
- 移植后的复发性FSGS导致显著的全移植损失和患者死亡率的增加.
- 目前缺乏达成共识的指导方针,阻碍了经常性FSGS的风险识别和管理.
研究的目的:
- 制定关于复发性FSGS的定义,流行病学,风险因素,病原和管理的共识指南.
- 为治疗移植后复发性FSGS患者的临床医生提供基于证据的建议.
主要方法:
- 在PubMed/Medline,Embase和Cochrane数据库中进行全面的文献搜索.
- 系统审查和鉴定研究的证据分级,以制定建议.
- 综合了221项选定的研究,以建立共识指南.
主要成果:
- 制定了指导方针,涵盖复发性FSGS的定义,流行病学,风险因素,病原和管理.
- 根据从经过审查的文献中获得的证据的强度来对建议进行分级.
- 确定需要进一步研究的关键领域,以加强现有建议.
结论:
- 已经建立了用于循环FSGS的共识指南,为临床实践提供了一个框架.
- 该指南强调需要进一步研究,以加强反复出现的FSGS的管理和预测.
- 解决复发性FSGS对于改善脏全移植生存率至关重要.
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