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尤卡斯基迪格拉紫来源的阿拉比诺银多糖增加了抗氧化能力,促进了肠道抗氧化功能

Xiangqi Fan¹, Xiangjun Xiao¹, Wei Yu¹

¹Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Key laboratory of Animal Disease-resistant Nutrition and Feed of China Ministry of Agriculture and Rural Affairs, Key laboratory of Animal Disease-resistant Nutrition of Sichuan Province, Chengdu 611130, People's Republic of China.

Carbohydrate polymers

|December 23, 2023

概括

一种来自Yucca schidigera提取物 (YSE) 的新型阿拉比诺加拉多糖,名为Yucca schidigera polysaccharide B (YPB),显示出强大的抗氧化活性. 通过激活NRF2通路并与特定细胞受体相互作用,YPB可以防止氧化应激.

科学领域:

植物生物化学植物生物化学
聚糖研究中的多糖.
氧化应激机制氧化应激机制

背景情况:

尤卡雪迪格拉提取物 (YSE) 显示出抗氧化能力.
识别YSE中的特定生物活性化合物对于了解其健康益处至关重要.
阿拉比诺银河动物是复杂的碳水化合物,具有多样化的生物活动.

研究的目的:

从YSE中分离和表征一种新型多糖.
为了阐明分离的多糖的结构.
研究多糖的抗氧化功能和潜在机制.

主要方法:

从YSE中分离和净化多糖.
单糖化合物组成分析和甲基化分析.
1D和2D核磁共振 (NMR) 光谱用于结构阐明.
在体外抗氧化剂测试和基于细胞的氧化应激模型 (IPEC-J2细胞,老鼠).
西方涂抹和抑制剂研究,以探索信号通路 (NRF2,PI3K/AKT).

主要成果:

一种同质的阿拉比诺甲多糖,Yucca schidigera多糖B (YPB),被分离出来 (24.2 kDa).
YPB含有Rha,Araf,Galp和Glcp,并确定了特定的葡萄糖化合物链接.
在体外和体内,YPB表现出显著的抗氧化能力,防止氧化应激.
YPB激活了NRF2通路,并保护IPEC-J2细胞和老鼠免受氧化损伤.
抗氧化作用涉及与表皮生长因子受体和曼诺酶受体的相互作用,激活PI3K/AKT通路.

结论:

玉米的多糖B (YPB) 是一种具有定义结构的新型同质阿拉伯.
YPB具有显著的抗氧化特性,有助于YSE的整体生物活性.
YPB通过NRF2和PI3K/AKT信号通路对氧化应激产生保护作用.

关键词:

抗氧化功能抗氧化功能肠道肠道肠道它是一种多糖化合物.结构结构是一个结构.尤卡斯基迪杰拉 (Yucca schidigera) 是一个植物.

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