声脂肪注射用于喉缺陷:系统性审查
Andrea M Campagnolo1, Jaqueline Priston2, Vinícius Nickel3
1Department of Otolaryngology-Head and Neck Surgery, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
声脂肪注射是一种安全有效的治疗喉缺陷 (GI),至少12个月改善声质. 需要进一步的研究来标准化技术并提高长期结果的可预测性.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 再生医学是一种再生医学.
背景情况:
- 喉缺陷 (GI) 影响声功能.
- 声脂肪注射提供了诸如曲性和干细胞潜力等优势.
- 胃肠道脂肪注射的长期结果仍然无法预测.
研究的目的:
- 系统地审查关于口腔脂肪注射的已发表文献.
- 评估脂肪注射喉腔整形的安全性和有效性.
主要方法:
- 在PubMed,Cochrane和Embase的系统文献搜索.
- 根据PICOTS和PRISMA陈述的纳入标准.
- 结果包括技术,持续时间,感知/声学分析和生活质量.
主要成果:
- 审查了13项研究,包括472名接受肠道脂肪注射喉膜整形的患者.
- 一年后,最大发音时间 (MPT) 和语音障碍指数 (VHI) 显著改善.
- 在技术 (收获,加工,注射) 和有限的客观评估中发现了异质性.
结论:
- 脂肪注射喉腔整形似乎是安全和有效的GI至少12个月.
- 报告了有利的结果,但局限性包括缺乏对照组和非标准化的方法.
- 进一步标准化和客观评估是必要的,以充分评估长期疗效.
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