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多参数流细胞计在评估血细胞增殖障碍时:临床实践当前范式

Ritu Gupta¹, Dragan Jevremovic², Smith J Mathew³

¹Department of Laboratory Oncology, Dr. BRAIRCH, AIIMS, New Delhi, India; Department of Hematology, Mayo Clinic, Rochester, MN.

Clinical lymphoma, myeloma & leukemia

|December 23, 2023

概括

多参数流细胞计 (MFC) 对于诊断血细胞增殖障碍 (PCPD) 至关重要. 该技术准确地识别和量化克隆性血细胞,有助于诊断,预后和监测治疗反应.

科学领域:

血液学血液学血液学
免疫学免疫学免疫学
在瘤学瘤学.

背景情况:

血细胞增殖障碍 (PCPD) 的特征是单克隆蛋白 (M-蛋白) 的产生.
诊断通常依赖于M蛋白检测,但理解克隆性血细胞增殖是关键.

研究的目的:

审查多参数流细胞计 (MFC) 在PCPD的诊断和管理中的重要作用.
突出MFC在表征和量化克隆性血细胞 (PC) 的实用性.

主要方法:

使用多参数流细胞计 (MFC) 来分析血细胞上的免疫类型标记物 (IPT).
根据克隆PC百分比区分良性,边缘性和恶性血细胞种群.

主要成果:

MFC准确地识别和量化克隆PC,区分MGUS,SMM,MM和PCL等实体.
在评估可测量的残留疾病 (MRD) 和监测MM和其他PCPD的疾病进展方面,MFC至关重要.
通过MFC帮助疾病预后和评估瘤微环境的特定IPT配置文件.

结论:

多参数流细胞计 (MFC) 是PCPD诊断的必不可少的工具,可以精确地表征和量化克隆性血细胞.
在MRD评估和治疗监测中,MFC的验证作用为预测患者结果提供了宝贵的见解.
MFC的应用扩展到疾病预后和理解瘤微环境,巩固其在管理PCPD中的重要性.

关键词:

循环等离子体细胞是循环等离子体细胞.克隆性血细胞是一种克隆性细胞.免疫型是一种免疫型.可测量的残留疾病.多发性骨髓瘤是一种多发性骨髓瘤.

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相关概念视频

Flow Cytometry

Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
In...