与子宫内膜异位症相关的不孕症:严重的疼痛症状不会影响辅助生殖技术的结果
C Maignien1,2, M Bourdon1,2,3, G Parpex1,2,3
1Faculté de Santé, Université de Paris, Paris, France.
Human reproduction (Oxford, England)
|December 23, 2023
概括
由子宫内膜异位症引起的严重疼痛不会影响辅助生殖技术 (ART) 活产率. 35岁以上的年龄和较低的抗穆勒尔激素水平是影响这些患者ART成功的主要因素.
科学领域:
- 生殖医学 生殖医学
- 妇科 妇科 妇科 妇科
- 不孕症治疗 不孕症治疗
背景情况:
- 辅助生殖技术 (ART) 是治疗子宫内膜异位症相关不孕症的关键治疗方法.
- 子宫内膜异位症疼痛对ART结果的影响仍未研究.
研究的目的:
- 调查与子宫内膜异位症相关的严重疼痛与ART活产率之间的关联.
- 确定影响子宫内膜异位症患者ART成功的因素.
主要方法:
- 354名接受ART治疗的子宫内膜异位症患者的观察队列研究.
- 在治疗前使用10点视觉模拟尺度 (VAS) 评估疼痛的严重程度.
- 每名患者的累积活产率 (CLBR) 作为主要结果指标.
主要成果:
- 严重的疼痛症状 (VAS ≥7) 在68.4%的患者中存在.
- 在患有和没有严重疼痛的患者之间,CLBR没有显著差异 (P=0.229).
- 年龄>35岁和抗穆勒尔激素<1.2 ng/ml是ART活产的显著负面预测因素.
结论:
- 与子宫内膜异位症相关的疼痛强度似乎没有影响ART活产率.
- 患者的年龄和卵巢储备是治疗子宫内膜异位症的ART成功的关键因素.
- 不孕期子宫内膜异位症患者的治疗决策需要采用多学科,个性化的方法.
相关概念视频
Infertility in Females
309
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
309
Oogenesis
63.7K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.7K
Disorders of the Female Reproductive System
366
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
366
Infertility in Males
269
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
269


