儿科重症监护室中阿片类药物引起便秘的发生率:描述性队列研究
Meghan D Roller1,2, Apurva Panchal3, Lori Duesing2,4
1Department of Pediatrics, Critical Care, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
JPEN. Journal of parenteral and enteral nutrition
|December 24, 2023
概括
阿片类药物引起的便秘 (OIC) 影响近40%的儿科重症监护室 (PICU) 患者. 虽然阿片类药物使用很常见,但其他因素,如神经问题,创伤或手术,也会导致重症儿童的便秘.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿片类药物引起的便秘 (OIC) 是阿片类药物止痛的已知的不良影响.
- 关于儿科重症监护室 (PICU) 中OIC的发病率和促成因素的数据有限.
- 了解PICU人群中的OIC对于优化患者护理和结果至关重要.
研究的目的:
- 为了确定小儿重症监护室 (PICU) 患者中OIC的发病率.
- 调查OIC与增加的发病率或延长停留时间 (LOS) 之间的潜在关联.
主要方法:
- 在12个月的时间内进行了单个中心的回顾性图表审查.
- 包括的患者年龄≤18岁,在PICU停留≥96小时,接受阿片类药物治疗.
- 收集的数据包括肠道排便频率,阿片类药物管理细节以及人口/临床信息.
主要成果:
- 在符合条件的患者中,有39.4%患上便秘.
- 便秘在年龄较大,体重较重的患者和因神经问题,创伤或腹部手术而入院的患者中更为普遍.
- 根据阿片类药物的剂量,持续时间或施用方法,或疾病的严重程度,没有发现便秘率的显著差异.
结论:
- 仅仅使用阿片类药物并不能仅仅预测PICU中的便秘.
- 除了阿片类药物管理之外的因素,如潜在的医疗条件和外科手术,在OIC发展中发挥着重要作用.
- 需要进一步的研究来阐明OIC在重症儿童的多因素原因.
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