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暴露和甲状腺激素干扰:一个系统的审查和元分析

Seung Min Chung¹, Min Cheol Chang²

¹Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Republic of Korea.

Reviews on environmental health

|December 24, 2023

概括

(Cd) 暴露没有显著影响甲状腺刺激激素 (TSH),自由甲状腺素 (FT4) 或甲状腺自身免疫. 然而,Cd暴露与三甲状腺素总水平 (TT3) 有积极的关联.

科学领域:

环境健康环境健康
内分泌学在内分泌学.
毒理学毒理学毒理学

背景情况:

(Cd) 是一种有毒的重金属,广泛暴露在环境中.
甲状腺激素对于新陈代谢调节和发育至关重要.
环境中有毒物质破坏甲状腺功能是越来越严重的公共卫生问题.

研究的目的:

系统地审查和元分析暴露与甲状腺激素干扰之间的关联.
评估对甲状腺刺激激素 (TSH),自由甲状腺素 (FT4),总三甲状腺素 (TT3) 和甲状腺自身免疫的影响.

主要方法:

在PubMed,Embase,Cochrane图书馆和Scopus中进行了全面的文献搜索,截至2022年12月14日.
包括的研究评估了血液中的 (BCd) 或尿液中的 (UCd) 与甲状腺功能或自身免疫性标志物之间的关系.
对12项横截面研究的数据进行了元分析.

主要成果:

暴露与TSH,FT4和甲状腺自身免疫有中性的关联.
观察到暴露与三甲基 (TT3) 总水平之间存在显著的正相关性.
这种与TT3的积极关联在血液和尿液子组分析中是一致的.

结论:

暴露于可能不会显著破坏TSH,FT4或甲状腺自身免疫.
暴露与增加的三甲基 (TT3) 总水平有关.
需要进一步的研究来阐明对TT3.3的影响背后的机制.

关键词:

和是最重要的元素.破坏内分泌的化学物质破坏内分泌的化学物质甲状腺是什么?甲状腺是什么?甲状腺自身免疫的发生.

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