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相关概念视频

Development of Immunocompetence01:22

Development of Immunocompetence

310
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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Transcytosis of IgG01:15

Transcytosis of IgG

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Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.8K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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相关实验视频

Updated: Jul 7, 2025

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
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[怀孕期间免疫细胞的功能]

Éva Pállinger1, Bence Nagy1, Anna Király2

  • 11 Semmelweis Egyetem, Általános Orvostudományi Kar, Genetikai, Sejt- és Immunbiológiai Intézet 1089 Budapest, Nagyvárad tér 4. Magyarország.

Orvosi hetilap
|December 24, 2023
PubMed
概括

成功怀孕取决于免疫系统的适应. 孕产妇的免疫系统经历着不同的炎症和抗炎症阶段,这对胎儿发育和预防感染至关重要.

关键词:
给所有的抗原.所有的抗原.免疫耐受性 免疫耐受性免疫不耐受性 免疫不耐受性怀孕 怀孕 怀孕 怀孕 怀孕三级电力公司热囊细胞的热囊细胞.

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相关实验视频

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科学领域:

  • 生殖免疫学 生殖免疫学
  • 孕产妇和胎儿医学 孕产妇和胎儿医学

背景情况:

  • 成功怀孕需要胎儿的免疫耐受性.
  • 决定化创造了一个对胚胎有竞争力的组织环境,决定作为内分泌和免疫器官.
  • 胚胎和母体组织之间的双向通信对于受精至关重要.

研究的目的:

  • 描述怀孕期间胎儿与母亲界面的动态免疫变化.
  • 了解母亲免疫系统适应成功怀孕的情况.
  • 探索免疫失调和妊娠并发症之间的联系.

主要方法:

  • 怀孕期间免疫阶段的审查,称为"免疫钟".
  • 分析母亲免疫,热囊细胞,激素和微生物组之间的相互作用.
  • 检查免疫系统在平衡耐受性,胎盘发育和感染防御方面的灵活性.

主要成果:

  • 怀孕经历了三个免疫学阶段:植入 (炎症),胎儿生长 (抗炎症) 和分娩 (炎症).
  • 成功的适应包括母亲对父亲抗原的免疫耐受性,胎盘的最佳发育和对病原体的保护.
  • 在胎儿与母亲的接口处建立一个专门的免疫环境,整合先天性和适应性免疫是必不可少的.

结论:

  • 了解母亲免疫系统的作用是诊断和治疗妊娠并发症的关键,如不孕症和植入失败.
  • 怀孕期间的免疫失调会导致不良结果.
  • 胎儿与母亲的接口需要一个微调的免疫反应,以保持健康的怀孕.