在极端选择偏差下拓测试的性能
Etai Markowski1,2, Edward Susko1
1Department of Mathematics and Statistics, Dalhousie University, Halifax, NS, Canada.
Molecular biology and evolution
|December 24, 2023
概括
在树木测试中,Simodaira-Hasegawa (SH) 测试过于保守,而其类型,Kishino-Hasegawa (KH) 测试,即使具有选择偏差,也表现良好. 大致概率测试 (aLRT) 也显示出强大的性能.
科学领域:
- 人类遗传学分析
- 计算生物学是一种计算生物学.
- 在家族遗传学中的统计推断.
背景情况:
- 传统的树测试方法,如基希诺-哈塞加瓦 (KH) 和奇方测试,容易受到选择偏差的影响.
- 希莫代拉-哈塞加瓦 (SH) 测试和大约无偏差测试是为了减轻这种偏差而开发的.
研究的目的:
- 在严重的选择偏差下评估树木测试方法的性能.
- 为了将基于概率的支持值与近似概率测试 (aLRT) 的支持值进行比较.
- 评估拓测试程序对分割支值的有用性.
主要方法:
- 通过控制选择偏差的模拟来研究树测试性能.
- 比较了Shimodaira-Hasegawa (SH) 测试,Kishino-Hasegawa (KH) 测试,以及奇方测试.
- 评估的近似概率测试 (aLRT) 支持值与基于概率的支持值.
主要成果:
- SH测试显示过于保守的行为.
- 在KH测试中,即使具有极端的选择偏差,I型错误率也很低.
- 奇方位测试通常表现良好,只需要在极端情况下进行校正.
- 尽管存在严重的选择偏差,aLRT支持值仍然合理.
- 拓测试程序可以产生可靠的分割支值.
结论:
- 由于SH测试的保守性,建议放弃SH测试.
- 在存在选择偏差的情况下,KH测试是SH测试的可行替代方案.
- 奇方测试通常是可靠的,但在极端情况下可能需要调整.
- aLRT为家族遗传分裂提供了强大的支持值,即使在具有挑战性的条件下也是如此.
- 在解释拓测试中的分支值时,考虑多重比较至关重要.
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