德国的质子抑制剂的处方模式:一项回顾性研究,包括472,146名患者
Kate Plehhova1, Monika Haering2, Joshua Wray1
1Reckitt Benckiser Healthcare Limited, Hull, UK.
Journal of primary care & community health
|December 24, 2023
概括
德国的质子抑制剂 (PPI) 使用显示出与2023年指南的显著偏差,只有4.5%的患者遵守治疗建议. 对轻度疾病的高剂量和长期PPI处方是常见的,这表明指导方针和实践之间存在差距.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 更新的2023年DGVS指南建议在升级到PPI之前对轻度GERD进行保守治疗.
- 质子抑制剂 (PPI) 广泛用于胃食道逆流病 (GERD) 和其他与酸有关的疾病.
- 了解PPI处方模式对于优化治疗和遵守临床指南至关重要.
研究的目的:
- 分析在德国使用质子抑制剂 (PPI) 的适当性.
- 评估德国医疗保健提供者之间的PPI处方实践.
- 为了比较现实世界的PPI处方与GERD的最新DGVS指南.
主要方法:
- 使用IQVIATM疾病分析器数据库 (2019年9月 - 2021年9月) 进行了回顾性横截面研究.
- 包括472,146名PPI使用者和9,101名来自德国1006家通用和39家胃肠病诊所的阿尔金酸盐使用者.
- 分析了PPI的指示,共同诊断,共同治疗,持续时间,剂量和处方做法.
主要成果:
- 只有4.5%的患者在完全遵守指南的情况下接受治疗.
- 常见的适应症包括胃炎/十二指肠炎 (47.2%) 和反流性疾病 (38.4%).
- 平均PPI治疗持续时间为141天,其中36.6%的患者接受了超过6个月的治疗;高剂量经常被处方.
结论:
- 目前在德国的PPI处方实践与DGVS指导方针之间存在重大差异.
- 高剂量和长时间的PPI处方适用于轻度的适应症需要注意.
- 需要进一步努力,使临床实践与最新的GERD管理指南保持一致.
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