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Updated: Jul 7, 2025

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
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这种BRCA2 R2645G变体增加了DNA结合,并诱导了超重组

Lucia Alvaro-Aranda1, Ambre Petitalot2,3, Yasmina Djeghmoum4,5

  • 1Genome Instability and Cancer Predisposition Laboratory, Centro de Biologia Molecular Severo Ochoa (CBMSO), CSIC-UAM, Madrid 28049, Spain.

Nucleic acids research
|December 24, 2023
PubMed
概括

一种BRCA2基因变异R2645G意外地增强了DNA修复,导致基因组不稳定性和对某些癌症疗法的敏感性增加. 这表明,严格调节BRCA2的DNA结合对于预防癌症至关重要.

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