皮肤吸收的表征方法:对有机酸盐的进展和前景
Zhexi Wang1, Shuxiang Geng1, Jiayi Zhang1
1School of Environment, Key Laboratory for Yellow River and Huai River Water Environment and Pollution Control, Ministry of Education, Henan Normal University, Xinxiang 453007, China.
Environment international
|December 24, 2023
概括
有机酸乙烯 (OPE) 是一种通过皮肤吸收而带来高人体健康风险的环境污染物. 本次审查强调了需要更好的体外方法来确定OPE的透系数 (Kp) 以进行准确的暴露评估.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 皮肤吸收研究 皮肤吸收研究
背景情况:
- 有机酸盐 (OPEs) 是普遍存在的环境污染物.
- 暴露于OPE对人类健康构成风险,特别是通过皮肤吸收.
- 目前用于量化OPE皮肤吸收的方法存在重大局限性.
研究的目的:
- 对评估OPE皮肤吸收的方法进行审查和批判性评估.
- 在OPE暴露评估中识别和讨论与透系数 (Kp) 参数相关的挑战.
- 为了总结体外方法,皮肤膜和影响OPE Kp 的因素.
主要方法:
- 对相对吸收 (RA) 和透系数 (PC) 模型进行皮肤吸收评估的审查.
- 对于Kp确定体外方法的总结.
- 识别常用的皮肤膜和影响K的因素.
主要成果:
- 电脑模型更准确,但依赖于OPEs的Kp值的不良特征.
- 目前对OPE的Kp数据有限,导致估计错误.
- 讨论了影响Kp的因素和相关的实验条件.
结论:
- 需要改进体外方法来准确确定OPE Kp值.
- 需要进行进一步的研究,以建立一个更复杂的OPE皮肤吸收评估实验系统.
- 解决Kp数据中的知识差距对于可靠的人类健康风险评估至关重要.
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