在创伤期间过度的外周和全身血管收缩在创伤后应激障碍中回忆:一个双胞胎控制研究
Zachary T Martin1, Amit J Shah2, Yi-An Ko1
1Rollins School of Public Health, Emory University, Atlanta, Georgia.
Biological psychiatry
|December 24, 2023
概括
创伤后应激障碍 (PTSD) 与创伤回忆期间更大的血管收缩有关. 这种过度的血管收缩可能解释了PTSD患者心血管疾病风险的增加.
科学领域:
- 心血管生理学心血管生理学
- 心理生理学 心理生理学
- 双胞胎研究 双胞胎研究
背景情况:
- 创伤后应激障碍 (PTSD) 与较高的心血管疾病 (CVD) 风险有关.
- 将PTSD与心血管疾病联系在一起的机制尚未完全理解.
- 这项研究研究了在PTSD中对创伤回忆的血管反应.
研究的目的:
- 为了测试患有PTSD的个体在个性化创伤回忆过程中是否表现出较高的外周和全身血管收缩.
- 探索潜在的PTSD和CVD风险的心理生理机制.
主要方法:
- 一项共同双胞胎对照研究设计用于179名年龄较大的男性双胞胎.
- 评估了终身PTSD史和当前的PTSD症状.
- 在中性和创伤脚本听力过程中测量了外周和全身血管度.
主要成果:
- 与非PTSD双胞胎相比,患有PTSD史的参与者在创伤回忆期间显著增加了外周和全身血管收缩.
- 这些发现在调整心血管风险因素,药物,心率和血压后仍然存在.
- 当前的PTSD症状严重程度与这些夸张的血管反应相关.
结论:
- 创伤后应激障碍与对创伤提醒的夸张血管缩反应有关.
- 这些过度的血管反应可能会导致患有PTSD的个体中观察到的心血管疾病风险增加.
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