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糖尿病视网膜病变中的葡萄糖运输,运输器和新陈代谢

Chaoyang Zhang¹, Limin Gu², Hai Xie¹

¹Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases; Shanghai Clinical Research Center for Eye Diseases; Shanghai Key Clinical Specialty; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Eye Research Institute, Shanghai, China.

Biochimica et biophysica acta. Molecular basis of disease

|December 24, 2023

概括

糖尿病视网膜病变 (DR) 是导致失明的主要原因,由高血糖驱动. 本综述探讨了视网膜中改变的葡萄糖运输和新陈代谢如何导致DR病变,并提出了潜在的治疗策略.

科学领域:

眼科医生眼科眼科
代谢障碍代谢障碍代谢障碍
细胞生物学细胞生物学

背景情况:

糖尿病视网膜病变 (DR) 是全球劳动年龄成人视力损失的主要原因.
高血糖引起的葡萄糖运输的改变是DR发展的核心.
通过血视网膜屏障 (BRB) 运输葡萄糖对于视网膜健康至关重要.

研究的目的:

审查DR中葡萄糖运输和代谢的变化.
检查葡萄糖载体 (GLUT,SGLT,SWEET) 在DR中的作用.
讨论这些变化如何影响视网膜神经血管单元 (NVU),并建议治疗方法.

主要方法:

文献综述侧重于视网膜中的葡萄糖运输机制.
对DR中高血糖受影响的生物化学途径的分析.
讨论代谢变化与DR病理之间的联系.

主要成果:

高血糖症增加了视网膜的葡萄糖吸收,并激活了有害的途径 (PKC,AGE,多,HBP).
这些途径产生活性氧物种 (ROS),导致氧化应激和PARP激活.
激活的PARP有助于视网膜微血管病变,神经退行和DR的炎症.

结论:

改变葡萄糖运输和新陈代谢是DR的关键驱动因素.
准葡萄糖运输和相关途径可能为DR提供治疗效益.
了解这些机制对于开发有效的DR疗法至关重要.

关键词:

糖尿病视网膜病变 - 糖尿病视网膜病变葡萄糖是一种葡萄糖.葡萄糖的新陈代谢.葡萄糖的运输方式葡萄糖运输器是葡萄糖的运输器.这就是SGLT2i.

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