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剖析神经回路从正面腹中枢髓到脊柱三角核,双向调节面机械灵敏度

Yang Xue¹, Siyi Mo¹, Yuan Li¹

¹Department of Prosthodontics, Center for Oral and Jaw Functional Diagnosis, Treatment and Research, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, PR China.

Progress in neurobiology

|December 24, 2023

概括

研究人员揭示了从面向腹中髓 (RVM) 到脊柱三角核 (Sp5) 的大脑电路如何控制面疼痛. 针对这些RVM-Sp5电路提供了治疗慢性面疼痛的潜在策略.

科学领域:

神经科学是一个神经科学.
疼痛研究疼痛研究
分子生物学分子生物学

背景情况:

慢性面疼痛很难治疗,其潜在机制尚不清楚.
众所周知,面腹中枢髓 (RVM) 影响下降疼痛调制.
在面疼痛中,RVM-脊柱三核 (Sp5) 电路的特定组织在很大程度上仍未得到研究.

研究的目的:

阐明RVM-Sp5电路在调节面视觉感受中的结构和功能.
确定参与疼痛缓解和抑制的特定神经元群体和途径.
探索操纵这些电路治疗慢性面疼痛的治疗潜力.

主要方法:

病毒追踪技术可以将RVM投影映射到Sp5.
在体内光遗传学和化学遗传学用于神经元活动的功能操纵.
信号记录用于监测 Sp5.5 中的神经元活动.
诱导马塞特超痛症模型 (炎症/功能障碍) 来研究疼痛状态.

主要成果:

投射到Sp5的RVM神经元主要是GABAergic (抑制性) 或glutamatergic (促进性).
接收RVM输入的Sp5GABAergic内部神经元具有反诺基感应效应,而Sp5谷氨基质投射神经元是前感应的.
接收RVM输入的GABAergic和glutamatergicSp5神经元都在质体过敏症期间被激活.
选择性激活针对RVM的Sp5GABAergic神经元或抑制针对RVM的Sp5谷氨酸神经元逆转了过敏症.

结论:

特定的RVM-Sp5神经元亚型及其投射差异调节面视觉.
通过激活抑制路径或抑制促进路径,准这些已识别的RVM-Sp5电路,可以缓解面肌肉疼痛.
这项研究为开发治疗难治的面疼痛的新疗法提供了基础.

关键词:

头骨面部的感觉是没有感觉的有GABA活性的神经元谷氨酸作用的神经元罗斯特拉的中腹腔中枢髓脊柱三胞胎核中的三胞胎核

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