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皮肤癌和艾滋病病毒

Cory Kosche¹, Martin T W Chio², Sarah T Arron³

¹Department of Dermatology, University of California Medical School, San Francisco, California, USA.

Clinics in dermatology

|December 24, 2023

概括

艾滋病毒感染者 (PLWH) 面临着不断变化的皮肤癌风险,特别是状细胞癌和其他罕见皮肤癌的发病率更高. 抗逆转录病毒疗法影响这些风险,需要量身定制的查和治疗指南.

科学领域:

皮肤病学皮肤病学
传染性疾病传染性疾病
在瘤学瘤学.

背景情况:

艾滋病毒感染者 (PLWH) 患皮肤癌的发病率受到抗逆转录病毒疗法 (ART) 的影响.
虽然角质细胞癌在PLWH和一般人群中都很常见,但PLWH可能具有状细胞癌的风险增加.
默克尔细胞癌和脂质癌在PLWH中发生率增加.

研究的目的:

审查目前对PLWH皮肤癌风险的理解.
讨论艾滋病毒,ART和免疫状况对皮肤癌的发展和治疗的影响.
突出需要为这一群体制定具体的查和治疗指南.

主要方法:

关于研究皮肤癌发病率,风险因素和PLWH治疗结果的文献综述.
分析艾滋病毒感染,抗逆转录病毒疗法,免疫状态和皮肤癌症发生之间的相互作用.
检查当前的查建议和治疗方法,包括莫斯微图手术和免疫检查点抑制剂.

主要成果:

与普通人群相比,PLWH可能会患有状细胞癌的风险更高.
在PLWH中观察到梅克尔细胞癌和脂质癌的发病率增加.
关于PLWH中黑色素瘤风险的数据不一致.
免疫检查点抑制剂在PLWH中似乎是安全和有效的,尽管需要进一步研究.

结论:

在PLWH中皮肤癌的风险是多因素的,受HIV,ART和免疫状况的影响.
警监测,量身定制的查和具体的治疗指南对于管理PLWH皮肤癌至关重要.
进一步的研究是必不可少的,以完善对这种人群皮肤癌的理解和管理策略.

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