脑部护理颗粒 (Cerebralcare Granule®) 结合记忆素对阿尔茨海默氏病的影响
Mingjuan Yang1, Xinyu Zhang1, Ou Qiao1
1School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
Journal of ethnopharmacology
|December 24, 2023
概括
这项研究表明,将Cerebralcare Granule (CG) 与记忆素 (Mm) 结合起来,显著改善了阿尔茨海默氏症患者的学习和记忆.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
背景情况:
- 阿尔茨海默病 (AD) 是老年人痴呆的主要原因.
- 传统中医 (TCM) 像Cerebralcare Granule (CG) 这样可以补充现代治疗方法.
- 孟曼丁 (Mm) 是一种NMDA受体对抗剂,是治疗AD的关键现代疗法.
研究的目的:
- 评估CG和MM对AD小鼠认知缺陷的综合影响.
- 在AD模型中研究CG + Mm治疗的潜在机制.
主要方法:
- 向D-银糖诱导的AD小鼠给予CG和Mm的组合.
- 进行行为,病理和蛋白质组分析.
- 评估了抗氧化酶活动,炎症标志物,突触可塑性,微细胞化和线粒体功能.
主要成果:
- CG + Mm显著改善了AD小鼠的学习和记忆,以及大脑病理.
- 治疗增强了抗氧化能力 (CAT,SOD,GSH-Px) 并减少了氧化应激 (MDA).
- CG + Mm调节了炎症因素,恢复了突触蛋白 (SYP,PSD-95),促进了Aβ细胞分裂,并改善了线粒体功能.
结论:
- 与Mm单独相比,CG和Mm的组合在治疗小鼠的AD类症状方面表现出更高的疗效.
- 这项研究为CG与Mm在阿尔茨海默病管理中的临床应用提供了科学基础.
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