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作为新型抗结核剂的基酸基抑制剂的合成和结构-活性关系

Baiyuan Yang1, Paridhi Sukheja1, Bo Qin1

  • 1Calibr, a Division of Scripps Research, La Jolla, CA 92037, USA.

Bioorganic & medicinal chemistry letters
|December 24, 2023
PubMed
概括

研究人员发现了一种新型化合物21b,它可以有效地抑制Mycobacterium tuberculosis (Mtb),即导致结核病 (TB) 的细菌. 这种有前途的候选药物显示出强烈的活性和良好的安全性,支持其进一步开发用于结核病治疗.

关键词:
抗结核病活动 抗结核病活动阿里尔硫酸 (aryl fluorosulfate) 是一种酸的化合物.结核病菌菌菌的结核病菌的结核病菌.药物动力学 药物动力学结构活动关系研究研究.SuFEx SuFEx 是一个交换硫 (VI) 化物交换硫 (VI) 化物

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