在治疗激活甲状腺眼病后的teprotumumab治疗后的重新激活
Catherine J Hwang1, Nicole P Rebollo1, Keegan B Mechels1
1From Department of Oculofacial Plastic Surgery, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
American journal of ophthalmology
|December 24, 2023
概括
针对甲状腺眼病的teprotumumab治疗在两年内显示出33%的持续反应率. 疾病的重新激活是常见的,导致80%的病例的亡回归,双眼视的长期改善最小.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺眼病 (TED) 是一种影响眼的自身免疫性疾病.
- 德图穆马布是一种新的生物治疗活性TED的方法.
- 了解长期治疗的疗效和复发对于患者管理至关重要.
研究的目的:
- 为了确定teprotumumab治疗后活性甲状腺眼病的复发和重新激活率.
- 为了评估teprotumumab对前和双眼视的影响的持久性.
主要方法:
- 追溯的病例系列,包括21名活跃TED患者接受了teprotumumab治疗.
- 再激活被定义为位的回归和临床活动评分 (CAS) 的恶化.
- 评估了二次结局,包括双眼视响应和长期位变化.
主要成果:
- 在17名初始响应者中,有8人 (47%) 经历了活性化,有2人 (12%) 经历了孤立的亡回归.
- 总体而言,在整个研究期间,33%的患者保持了反应 (平均随访没有指定).
- 平均回归时间为12.25个月;没有观察到双眼视的显著变化.
结论:
- 活跃TED中对teprotumumab的长期反应有限,高达33%的患者在两年内继续获得益处.
- 疾病的重新激活是teprotumumab治疗后proptosis回归的一个重要因素.
- 在活跃的TED患者中,teprotumumab对双眼视的长期改善最小.
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