循环神经遗传学及其对神经生理学,行为学和时间医学的影响
Muhammad Naveed1, Owen Y Chao2, Jennifer W Hill3
1Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812, USA; Department of Physiology and Pharmacology, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH 43614, USA.
Neuroscience and biobehavioral reviews
|December 24, 2023
概括
身体自然昼夜节律的干扰与大脑疾病有关. 了解时钟基因及其在神经生理学中的作用是开发新疗法和提高药物有效性的关键.
科学领域:
- 时间生物学 时间生物学
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
背景情况:
- 循环节律调节生理过程;干扰涉及疾病途径.
- 人们越来越了解时钟基因在神经系统功能中的作用.
- 循环时间影响药物的疗效和毒性 (药理动力学).
研究的目的:
- 审查最近在理解昼夜时钟分子机制影响神经生理学和大脑疾病的行为方面的进展.
- 为了将人类大脑疾病的遗传研究与时钟基因变异联系起来.
- 讨论饮食和药物对昼夜节律的影响,并促进时间医学.
主要方法:
- 对模型生物和人类的昼夜节律现有文献的综述.
- 遗传学研究的摘要,将人类时钟基因变异与大脑疾病联系起来.
- 对饮食和药物对昼夜时间的影响的分析.
主要成果:
- 循环节律在遗传,细胞和神经电路层面上受到调节.
- 人类时钟基因变异与特定的大脑疾病有关.
- 饮食因素和药物可以显著影响人类的昼夜节律.
结论:
- 生物钟对神经生理学的影响的分子机制正在变得越来越清晰.
- 时钟基因的遗传变异在人类大脑疾病中起作用.
- 时间医学,将昼夜生物学整合到治疗中,具有重要的治疗潜力.
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