分子伴侣和折叠酶在维护内质网膜恒常状态方面的基本功能
Linda M Hendershot1, Teresa M Buck2, Jeffrey L Brodsky2
1Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, United States.
Journal of molecular biology
|December 24, 2023
概括
细胞内膜网膜 (ER) 使用分子伴侣来确保蛋白质折叠和预防疾病. 然而,EV的EV
科学领域:
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 高达三分之一的人类蛋白质进入内分泌网膜 (ER) 进行折叠和修饰.
- 在ER中蛋白质生物发生的忠实性对细胞健康至关重要,突变会影响与疾病相关的这一过程.
- 该ER含有多样化的分子伴侣,包括基于莱克的系统和细胞质伴侣的同类物,以管理蛋白质折叠并防止聚合.
研究的目的:
- 审查维护ER质量控制的因素的功能和相互作用.
- 突出各种陪伴者在ER内的蛋白质生物生成中的作用.
- 讨论较高的真核生物中有限的陪伴家族成员的影响.
主要方法:
- 对ER蛋白折叠和质量控制研究的文献综述.
- 在ER中分析特定的陪伴家族 (Hsp70,Hsp90,Hsp110) 的角色.
- 在ER的陪伴系统与细胞质的比较.
主要成果:
- 该ER采用复杂的伴侣系统,包括讲解蛋白和识别同类物,以确保蛋白质折叠.
- 在一些陪伴系统中的冗余性可以防止压倒性的折叠性受损基板.
- 较高的真核 ER 具有 Hsp70,Hsp90 和 Hsp110 家庭的单一成员,与细胞质不同.
结论:
- ER的质量控制机制对于细胞功能和预防疾病至关重要.
- 在ER的某些护送家庭的有限多样性带来了潜在的脆弱性.
- 了解ER伴侣相互作用是解决蛋白质错折疾病的关键.
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