最初无法切除的肝细胞癌的转化疗法:目前的状况和前景
Ya-Nan Ma1,2, Xuemei Jiang1, Hui Liu3
1Department of Gastroenterology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
Bioscience trends
|December 24, 2023
概括
对于不可切除的肝癌,转化疗法可以改善手术后的存活率. 然而,联合治疗增加了手术并发症,需要进一步研究疗效和患者选择.
科学领域:
- 肝细胞癌研究 肝细胞癌研究
- 在瘤学瘤学.
- 手术瘤学手术瘤学
背景情况:
- 局部和/或全身治疗可以降低不可切除的肝细胞癌 (HCC) 进行外科切除的阶段.
- 转化疗法之后的治愈性手术比其他治疗方式提供了显著的生存益处.
研究的目的:
- 评估对不可切除的HCC转化疗法的疗效和并发症.
- 突出结合局部区域加系统转换疗法的好处.
- 强调需要确立的标准和进一步的临床证据.
主要方法:
- 对HCC转换疗法的现有研究进行审查.
- 对转换率,客观缓解率和疾病控制率的分析.
- 评估与转化疗法相关的并发症.
主要成果:
- 转化疗法的成功率差异很大 (0.8%~60%).
- 地方区域加上全身疗法的联合疗法显示出高效率 (高达60%的转化率,96%的客观缓解,100%的疾病控制).
- 转化疗法显著增加了肝毒性和手术困难等并发症.
结论:
- 转化疗法,特别是组合疗法,可以使治疗性手术成为可能,并改善HCC患者的生存率.
- 增加的手术并发症需要仔细的患者选择和管理.
- 进一步的临床证据和标准化的评估标准对于优化转化疗法至关重要.
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