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CAR分子的细胞分裂调节了CAR-T细胞功能障碍和瘤抗原逃逸

You Zhai1,2, Yicong Du3, Guanzhang Li1,2

  • 1Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, PR China.

Signal transduction and targeted therapy
|December 24, 2023
PubMed
概括

瘤细胞可以通过高细胞分裂从CAR-T细胞中窃取化学抗原受体 (CAR) 分子,导致CAR-T细胞功能障碍和治疗抵抗. 这种新的机制突出了改善CAR T细胞治疗疗效的新治疗目标.

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