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阻止微流体的流动

Mehmet Akif Sahin1, Muhammad Shehzad1, Ghulam Destgeer1

  • 1Control and Manipulation of Microscale Living Objects, Department of Electrical Engineering, School of Computation, Information and Technology (CIT), Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Einsteinstraße 25, 81675, Munich, Germany.

Small (Weinheim an der Bergstrasse, Germany)
|December 24, 2023
PubMed
概括
此摘要是机器生成的。

我们比较了三种停止流的配置,以快速停止微通道流. 低压停止流 (LSF) 配置实现了最低的剩余速度,特别是在高阻力微通道中.

关键词:
通过3D打印打印3D打印.计算流体动力学的流体动力学.控制流量的流量控制器.流式 lithography 石版画 流式石版画 石版画流体电容容量 流体电容容量停止流动 停止流动

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科学领域:

  • 流体动力学 流体动力学
  • 微流体学 微流体学
  • 生物技术是生物技术.

背景情况:

  • 精确的微通道流量控制对于药物输送和诊断等应用至关重要.
  • 现有的停止流量方法可以留下剩余流量,影响实验精度.
  • 了解导致残留流量的因素对于优化微流体系统至关重要.

研究的目的:

  • 为了比较三种不同的止流配置的性能:低压 (LSF),高压开路 (OC-HSF) 和高压短路 (SC-HSF).
  • 为了量化微通道中的残余速度,具有不同的流电阻.
  • 为了研究流体电路在剩余速度中的合规性的作用.

主要方法:

  • 对LSF,OC-HSF和SC-HSF止流配置进行实验性交叉比较.
  • 在微通道中测量剩余流速,流动阻力有三次大小差异.
  • 数字建模以评估流体电路合规性 (微通道壁和管道弹性) 对残留流量的影响.

主要成果:

  • 这种LSF配置表现出了卓越的性能,在高阻力微通道中实现了<10μm s-1的剩余速度.
  • 在低阻力微通道中,OC-HSF导致<150μm s-1的剩余速度.
  • SC-HSF显示<200μm s−1的剩余速度跨通道和<100μm s−1在低阻力通道.
  • 实验和数值结果证实,流体电路合规性是剩余速度的主要原因.

结论:

  • 低压停止流 (LSF) 配置是实现微通道中几乎完全停止流动的最有效方法,特别是那些流动阻力高的微通道.
  • 流体电路合规性,包括微通道壁和连接管道的弹性,对剩余速度做出了重大贡献.
  • 开发的数值模型准确地根据电路合规性预测了剩余流量,有助于设计更精确的微流体系统.