尿道草甘暴露与老年人认知障碍之间的关联来自NHANES 2013-2014年
Jiawen Ren1, Yongquan Yu1, Yucheng Wang1
1Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China.
Journal of Alzheimer's disease : JAD
|December 25, 2023
概括
暴露于除草剂草甘可能与老年人的认知能力下降有关. 这项研究发现尿液中的草甘水平与老年人记忆力和流利性受损之间存在关联.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
背景情况:
- 草甘是一种广泛使用的除草剂,可疑具有神经毒性作用.
- 有限证据表明草甘暴露与认知障碍有关,特别是在老年人中,是有限的.
研究的目的:
- 调查尿液中的草甘水平与美国老年人认知障碍之间的关联.
- 评估草甘暴露对特定认知功能的影响.
主要方法:
- 利用了2013-2014年国家健康和营养检查调查 (NHANES) 的数据.
- 使用CERAD即时回忆 (IR),CERAD延迟回忆 (DR),动物流利性 (AF) 和数字替换 (DSST) 测试来评估认知功能.
- 员工调查加权后勤回归和受限立方线,以分析草甘与认知障碍之间的关联.
主要成果:
- 在465名老年参与者中,有83.87%的参与者有可检测的尿草甘.
- 较高的草甘水平与延迟回忆 (DR) 和动物流利性 (AF) 测试 (OR分别为1.52和1.69) 的损害显著相关.
- 在即时回忆 (IR) 或数字替换 (DSST) 测试中没有发现显著的关联.
结论:
- 草甘暴露可能与老年人群的认知功能下降有关.
- 需要进一步评估暴露于草甘的老年人认知结果.
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