在美国退伍军人中阿尔茨海默病阶段过渡
Peter Morin1, Byron J Aguilar2, Xuyang Li2
1Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Journal of Alzheimer's disease : JAD
|December 25, 2023
概括
阿尔茨海默病 (AD) 阶段之间的平均进展时间为2至4年. 这一发现凸显了及时启动治疗和更新临床指南的必要性,以有效管理AD.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 阿尔茨海默病 (AD) 和相关的痴呆症是渐进性的神经系统疾病.
- 关于患者在AD阶段之间过渡所需的时间,存在一个关键的知识差距.
- 了解这些过渡时间对于及时启动治疗,包括抗粉样蛋白疗法至关重要.
研究的目的:
- 为了确定美国退伍军人阿尔茨海默病 (AD) 的阶段过渡时间.
- 在退伍军人事务医疗保健系统 (VAHS) 内的认知测试成绩基础上分析过渡.
主要方法:
- 从2010年至2019年,对296519名患有AD的退伍军人进行了回顾性分析.
- 阿尔茨海默病的分期是使用微型心理状态检查 (MMSE),蒙特利尔认知评估 (MoCA) 或圣路易斯大学心理状态 (SLUMS) 评分从电子健康记录 (EHR) 来确定的.
主要成果:
- 在研究期间,使用MMSE的比例下降,而使用SLUMS和MoCA的比例增加.
- 在AD阶段 (轻度认知障碍到中度/重度AD) 之间过渡的平均时间约为2-4年.
- 在MMSE,MoCA和SLUMS评估中,过渡时间一致.
结论:
- 在VAHS中,对AD的认知评估的平均过渡时间为2-4年.
- 这一短暂的窗口强调了早期干预疾病修饰疗法的重要性.
- 这些发现强调需要更新治疗指南,以优化AD管理.
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