基于氨基酸的肠道营养对儿科克罗恩病有效:一项多中心前性研究
Qingfan Yang1,2,3, Ting Zhang4, Na Diao1,2,3
1Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
基于氨基酸的排他性肠道营养 (EEN) 有效治疗活跃的儿科克罗恩病 (CD),诱导缓解并改善肠道愈合. 这种安全的治疗方法对治疗儿科CD患者有前途.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 临床营养学 临床营养学
- 炎症性肠道疾病研究研究
背景情况:
- 独家肠道营养 (EEN) 是小儿克罗恩病 (CD) 缓解的主要疗法.
- 关于EEN中基于氨基酸的配方对儿科CD的疗效的数据有限.
- 这项研究解决了在活跃儿科CD中基于氨基酸的EEN的证据需求.
研究的目的:
- 为了前性地评估基于氨基酸的配方的疗效EEN在儿科患者活跃的CD.
- 评估临床缓解,粘膜愈合和炎症/营养标志物.
- 为了确定基于氨基酸的EEN在这个人群中的安全性概况.
主要方法:
- 在中国四家医院中,对患有活跃CD的儿科患者 (6-17岁) 进行前性研究.
- 8周的EEN干预使用基于氨基酸的配方.
- 在基线,4周和8周使用配对t测试和威尔科克森签名等级测试评估炎症和营养指数.
主要成果:
- 儿童克罗恩病活动指数 (CDAI) 的显著降低 (P < 0.001).
- 66.7%的患者实现了完全的临床缓解,45.5%的患者实现了完全的粘膜愈合.
- 炎症标志物和营养指数显著改善 (P <0.05),没有严重的不良影响.
结论:
- 基于氨基酸的EEN是一种有效和安全的治疗儿科发病的CD.
- 需要进一步的大规模,机械和后续研究来证实这些发现.
- 这种疗法为管理活跃儿科CD提供了一个有希望的选择.
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