在儿科移植接受者的多药耐药性感染的方法
Sara W Dong1, Tanvi S Sharma2, Paul K Sue3
1Division of Infectious Diseases, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA, United States.
Frontiers in pediatrics
|December 25, 2023
概括
耐多药格拉姆阴性细菌感染对儿科移植患者构成风险. 优化治疗和预防策略对于改善患者和移植存活至关重要.
科学领域:
- 儿童传染病 儿童传染病
- 移植医学 移植医学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 耐多药格拉姆阴性 (MDRGN) 细菌感染越来越多地在儿科固体器官和血液细胞移植接受者中被发现.
- 这些感染与这一脆弱人群的显著发病率和死亡率有关.
研究的目的:
- 在儿童移植患者中评估,管理和预防MDRGN感染方面提出临床挑战.
- 为管理这些复杂的感染提供一个框架.
主要方法:
- 案例简介说明了临床情景.
- 讨论当前和新型抗微生物方法.
- 审查包括感染控制和抗微生物药物管理在内的预防策略.
主要成果:
- 源控制和基于体外敏感性的适当抗生素选择至关重要.
- 识别复杂的抵抗机制可能需要专门的测试.
- 治疗选择包括新药,长时间输液和组合疗法.
结论:
- 优化对MDRGN感染的治疗和预防策略至关重要.
- 有效的管理影响了儿科移植接受者的患者和移植存活率.
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