抗精神病药对益生菌瘤生长的影响:放射学和血清学分析
Umar S Durrani1, Satvik Vasireddy2, Maha Z Arshad3
1Medicine, Saint Louis University School of Medicine, Saint Louis, USA.
Cureus
|December 25, 2023
概括
抗精神病药物可以增加益生菌水平,可能影响益生菌瘤. 停止使用某些抗精神病药物或转换为其他抗精神病药物,如阿里皮普拉,可能会降低益生菌素,但它们对益生菌瘤大小的直接影响尚不清楚.
科学领域:
- 内分泌学 在内分泌学.
- 神经药理学神经药理学
- 在瘤学瘤学.
背景情况:
- 超多巴胺激素与精神病有关,由降低多巴胺的抗精神病药物 (APs) 管理.
- 多巴胺激动剂 (DAs) 通过减少益生菌素分泌来有效治疗益生菌瘤.
- 抗生素对益生菌瘤大小的影响仍未得到充分研究,尽管它们对益生菌素水平的已知影响.
研究的目的:
- 为了研究抗精神病药物对益生菌瘤大小的影响.
- 在患有前性瘤的患者中分析与特定抗精神病药物相关的前性素水平变化.
主要方法:
- 进行了PubMed搜索,寻找同步接受AP治疗的益生菌瘤患者的研究.
- 鉴定和分析了涉及32名患者的27项研究的数据.
- 检查了七种特定抗精神病药物的作用:瑞斯佩里,哈洛佩里多尔,阿米苏普里德,蒂奥里达,阿里皮普拉,奥兰扎和克洛扎.
主要成果:
- 里斯佩里,哈洛佩里多尔,阿米苏普里德和蒂奥里达一般会增加益生素水平;停止治疗导致显著下降 (66-89.7%).
- 当作为其他AP的替代品使用时,阿里皮普拉,奥兰zapine和clozapine显示出显著的益生菌减少 (54-68%).
- 由于同时使用DA,成像限制以及手术或放射治疗等治疗方法,直接评估AP对益生菌瘤大小的影响具有挑战性.
结论:
- 停止服用某些抗精神病药物可能会导致患有益生菌瘤的患者的益生菌水平降低.
- 单个抗精神病药物在益生菌瘤形成或生长中的特定作用需要进一步研究.
- 虽然APs会影响益生素水平,但它们对益生素瘤大小的直接影响很难从当前的文献中确定.
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