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相关概念视频

Immunological Memory01:23

Immunological Memory

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Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Humoral Immune Responses01:36

Humoral Immune Responses

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Overview
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

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The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
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相关实验视频

Updated: Jul 7, 2025

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity
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人体IgM表达的B细胞记忆细胞

Bettina Budeus1, Artur Kibler1, Ralf Küppers1

  • 1Institute of Cell Biology (Cancer Research), Medical Faculty, University of Duisburg-Essen, Essen, Germany.

Frontiers in immunology
|December 25, 2023
PubMed
概括

大多数成年人的记忆B细胞表达IgM和突变的基因来源于生殖中心反应. 这与一些早期的B细胞形成鲜明对比,突出显示了多样化的免疫记忆起源.

科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 人体生理学 人体生理学

背景情况:

  • 依赖T细胞 (TD) 的幽默免疫依赖于长寿记忆B细胞,这些B细胞是在生殖中心 (GC) 反应过程中产生的.
  • GC反应涉及B细胞增殖,免疫球蛋白V (IgV) 基因的体态突变,以及对高亲和度B细胞抗原受体的选择.
  • 虽然在历史上强调了类切换记忆B细胞 (IgG,IgA),但也存在大量表达IgM的记忆B细胞.

研究的目的:

  • 研究具有体质突变的IgV基因的独特的人类IgM表达B细胞子集的起源.
  • 澄清生殖中心反应在产生这些特定记忆B细胞群中的作用.

主要方法:

  • 在人类B细胞群中对免疫球蛋白V (IgV) 基因体质突变的分析.
  • 对IgM+记忆B细胞和类切换记忆B细胞的表型和功能特征进行比较.
  • 在生殖中心反应和其他潜在起源的背景下,追踪B细胞的分化途径.

主要成果:

  • 绝大多数成年人体IgM表达B细胞与体质突变的IgV基因来自生殖中心 (GC) 反应.
  • 具有体质突变IgV基因的人类IgM+B细胞的不同子集与类切换记忆B细胞表现出相似之处和差异.
  • 低突变IgM+B细胞的少数群体可能起源于其他差异化途径,特别是在生命早期.
关键词:
B 细胞 B 细胞 B 细胞CD27 CD27 CD27 CD27 CD27 CD27 CD27 CD27 CD27 CD27 CD27 CD27 CD27在 IgD 的情况下,IgD 是类开关重组组合类开关重组发芽中心的发芽中心.免疫球蛋白V的基因边缘区域边缘区域的边缘区域身体上的超突变.

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结论:

  • 生殖中心反应是体质突变的主要来源,成年人体内的IgM表达记忆B细胞.
  • 了解不同记忆B细胞子集的起源对于理解适应性免疫和免疫记忆至关重要.
  • 进一步的研究可能会阐明GC衍生的和潜在的非GC衍生的IgM+B细胞的特定作用和发育轨迹.