轻度行为障碍,睡眠障碍和进展为痴呆症之间的纵向关联
Dinithi Mudalige1, Dylan X Guan1, Maryam Ghahremani2
1University of Calgary, Calgary, AB, Canada.
Journal of Alzheimer's disease reports
|December 25, 2023
概括
轻度行为障碍 (MBI) 和睡眠障碍 (SD) 有着双向的关系. 患有MBI和SD的老年人表现出痴呆症风险增加,建议进行综合评估以改善查.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 临床指南建议将轻度行为障碍 (MBI) 和睡眠障碍 (SD) 等非认知标志物纳入痴呆症查中.
- 通过考虑这些标志物,可以改善早期发现痴呆症.
研究的目的:
- 调查MBI,SD和痴呆症发病率之间的纵向关联.
- 探索MBI和SD之间的双向关系随着时间的推移.
主要方法:
- 利用了来自美国国家阿尔茨海默氏症协调中心 (NACC) 的数据.
- 采用Cox比例危险回归与时间依赖变量进行模型关联.
- 分析了MBI阳性个体中的事件SD,SD阳性个体中的事件MBI,以及基于MBI和SD状态的事件痴呆.
主要成果:
- 在基线时患有MBI的老年人患SD的比率高3.1倍.
- 患有基线SD的老年人患上MBI的几率高1.5倍.
- 与单独患有SD的人相比,MBI和SD的个体中痴呆症发病率是MBI和SD的2.2倍.
结论:
- 在MBI和SD之间存在双向关系.
- 在老年人中,MBI和SD的同时出现显著增加了痴呆症的风险.
- 对MBI和SD的评估可能会增强痴呆症查协议.
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