功能和形态成熟的全尺寸和迷你猪体黄体通过编程细胞死亡机制的功能和形态成熟
Ji-Hye Lee1, Sang-Hwan Kim1,2
1Institute of Applied Humanimal Science, Hankyong National University, Ansung, Gyeonggi-do, 17579, Republic of Korea.
Journal of veterinary research
|December 25, 2023
概括
在约克郡和迷你猪之间,黄体 (CL) 功能有所不同,约克郡猪显示较高的黄素化激素和矩阵金属蛋白酶 (MMP) 活性,而迷你猪则表现出潜在的孕抑制. 自与CLs中的细胞重组相关.
科学领域:
- 生殖生物学 生殖生物学
- 细胞生物学 细胞生物学
- 兽医科学是一门兽医科学.
背景情况:
- 黄体 (CL) 的形成和功能对于怀孕和植入至关重要.
- 亡的时间对CL功能至关重要,但亡类型的影响仍然不清楚.
研究的目的:
- 为了研究约克郡猪和迷你猪之间的黄体 (CL) 细胞组成,激素表达和亡的差异.
- 探索不同猪品种的自,矩阵金属蛋白酶 (MMP) 和CL功能之间的关系.
主要方法:
- 约克郡和迷你猪在雌性周期第15天的CLs的形态分析.
- 使用免疫试验和mRNA水平测量激素表达和亡.
- 评估矩阵金属蛋白酶 (MMP) 活性,caspase3和20alpha-hydroxysteroid脱酶的表达.
主要成果:
- 与迷你猪相比,约克郡猪具有更均的CL细胞,更完整的组成和更高的黄素激素表达.
- 在约克郡猪中,矩阵金属蛋白酶 (MMP) 活性较高,而在小猪中,酶3和孕激素抑制剂表达被强化.
- 约克郡猪的自更广泛,与MMP介导的细胞重组相关.
结论:
- 自和MMP驱动的细胞重组在红体 (CL) 中高度相关.
- 在CL形成和功能中自的程度可能会影响激素作用和细胞复合因素.
- 品种特有的CL亡和自的差异影响生殖效率.
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